Ion channels and transporters are crucial for life. Without these proteins, the heart will stop beating, and we will be unable to flex our muscles, see, smell, hear, taste, and think. The goal of this course is to introduce the fundamental concepts of molecular physiology of ion channels and transporters. The emphasis will be on the electrophysiological and optical methods used for investigating ion transport proteins. Specific topics will include ion channel biophysical characteristics and ion channel/transporter modulation and function. Two laboratory demonstrations will help students to master the learned concepts in a real experimental setting.