Advanced Concepts in Cytosolic and Nuclear Signal Transduction
Cellular signal transduction mechanisms comprise a complex communication network that governs cellular function and responses. These networks include communication between cells as well as that within cells. Signaling networks govern the ability of cells to perceive and correctly respond to their surroundings and are therefore critical in organ development, tissue repair, and homeostasis. Errors in signaling responses can result in diseases including cancer, neurodegeneration, pain, osteoporosis, autoimmunity, and diabetes. The potential modulation of cellular signaling networks is the basis of current research in disease in the 21st century. This course is designed to give graduate students in biological sciences a state-of-the-art education in cellular signaling mechanisms and the methodology used to study them. Landmark and breaking scientific journal articles in various signaling fields will be discussed and critically evaluated. Emphasis is given to both experimental design and results interpretation. Prior education in biochemistry and cell biology is required. By the end of this course, students will have a state-of-the-art current knowledge of the cytosolic and nuclear mechanisms of cellular signaling pathways. Students will have a working to design experiments to study signaling pathways, and how to interpret results. Students will have gained the skill of how to read, interpret, and critically evaluate published journal articles in the fields of cellular signaling mechanisms.