Chromosome Instability and Disease
This is a lecture-based one credit module that will be offered every other year to all incoming basic science doctoral graduate students in the School of Medicine programs or other interested graduate students and fellows. The format will be 1.5 hour discussion and lecture sessions. This class will explore the mechanisms and consequences of chromosome instability ranging from congenital chromosome abnormalities to cancer. Topics will include the normal structure and function of chromosomes and how failures in these functions promote chromosome instability both in meiosis and mitosis. The associated clinical consequences of chromosome instability in miscarriage, birth defects and cancer will be discussed.